Interrelationships between Experimental Hypercholesteremia, Magnesium Requirement, and Experimental Atherosclerosis

Successive prevention of experimental hypercholesteremia and cholesterol atherosclerosis in the rabbit.

Influence of Dietary Magnesium on Cardiac and Renal Lesions of Young Rats Fed an Atherogenic Diet

Young male rats fed an atherogenic diet for 24 to 26 days developed magnesium deficiency. The renal lesions, calcium deposition in tubular lumens in the outer zona intermedia, are morphologically consistent with those seen in animals fed magnesium-free diets. It was necessary to feed 8 to 16 times the normal requirement of magnesium to prevent completely these lesions. The limitations in the pa...

Studies of interrelationships of thyroxine, magnesium, and vitamin B12.

The increased requirement for vitamin Blz in thyrotoxic animals is well established (l-3). Vitale et al. (4) have demonstrated that magnesium will also partially overcome the growth-inhibiting action of thyroxine administration. Uncoupling of oxidative phosphorylation occurs in rats made magnesium-deficient either by dietary deprivation of magnesium (5) or by thyroxine administration (4). In vi...

Endothelial cells and magnesium: implications in atherosclerosis.

There is no doubt that the functional and structural integrity of the endothelium is critical in maintaining vascular homoeostasis and in preventing atherosclerosis. In the light of epidemiological and experimental studies, magnesium deficiency is emerging as an inducer of endothelial dysfunction. In particular, data on the effects of low extracellular magnesium on cultured endothelial cells re...

Observations concerning the Cholate: Cholesterol Relationship

The occurrence of hypercholesteremia in the nephrotic state is a long recognized phenomenon (1), but its mechanism remains to be determined. Apparently the hypercholesteremia cannot be ascribed to a primary "lipoid degeneration" of the kidney (2). Recently, studies from this laboratory (3-6) have indicated that there is a marked derangement of cholate metabolism in certain clinical and experime...